Figure 1.

BioCreAtIvE Evaluation Tool (subtask 2.2). showing GO annotation of 'kinase activity' GO:0016301 (right tool bar) by user 9-1 with supporting text evidence (central panel). The left tool bar shows the UniProt accession number, in this case Q8IWU2 has been annotated. Q8IWU2 represents a KPI-2 protein so the user has been evaluated based on the evidence text as 'high' for GO term prediction and 'high' for representing the correct gene product. The user also uses this sentence to predict the GO term 'receptor signaling protein serine/threonine kinase activity'(GO:0004702). Although that GO annotation is correct for this protein the evidence text supplied does not support that level of detail. The same evidence text was evaluated as 'general' for the GO term prediction of GO:0004702 (same lineage as correct GO term 'kinase activity') and 'high' for representing the correct gene product.

Camon et al. BMC Bioinformatics 2005 6(Suppl 1):S17   doi:10.1186/1471-2105-6-S1-S17