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Significant differences between the control set and disease set of genes. The features found to be significantly different between Ensembl genes found in OMIM and those not in OMIM. Significance was calculated using the Mann-Whitney U test unless otherwise noted. |
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| Feature |
Median in control set |
Median in disease set |
Significance |
|
|
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| Gene length |
19 k |
27 k |
P < 0.001 |
| cDNA length |
2,126 bp |
2,442 bp |
P < 0.001 |
| Protein length |
383 aa |
494 aa |
P < 0.001 |
| 3' UTR length |
446 bp |
488 bp |
P < 0.01 |
| Exon number |
8 |
10 |
P < 0.001 |
| Distance to neighbouring gene |
46 kb |
52 kb |
P < 0.01 |
| Protein identity with BRH in mouse |
80% |
87% |
P < 0.001 |
| Gene encodes signal peptide |
17% |
35% |
P < 0.0001 (calculated using the chi squared test) |
| 5' CpG islands |
12% |
16% |
P < 0.028 (calculated using the chi squared test) |
Adie et al. BMC Bioinformatics 2005 6:55 doi:10.1186/1471-2105-6-55 |
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