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Open Access Software

T.I.M.S: TaqMan Information Management System, tools to organize data flow in a genotyping laboratory

Stéphanie Monnier1, David G Cox2, Tim Albion3 and Federico Canzian14*

Author Affiliations

1 International Agency for Research on Cancer, F-69372, Lyon, France

2 Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA

3 Menzies Research Institute, University of Tasmania, Hobart 7001, Australia

4 German Cancer Research Center (DKFZ), D-69120, Heidelberg, Germany

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BMC Bioinformatics 2005, 6:246  doi:10.1186/1471-2105-6-246

Published: 12 October 2005

Abstract

Background

Single Nucleotide Polymorphism (SNP) genotyping is a major activity in biomedical research. The Taqman technology is one of the most commonly used approaches. It produces large amounts of data that are difficult to process by hand. Laboratories not equipped with a Laboratory Information Management System (LIMS) need tools to organize the data flow.

Results

We propose a package of Visual Basic programs focused on sample management and on the parsing of input and output TaqMan files. The code is written in Visual Basic, embedded in the Microsoft Office package, and it allows anyone to have access to those tools, without any programming skills and with basic computer requirements.

Conclusion

We have created useful tools focused on management of TaqMan genotyping data, a critical issue in genotyping laboratories whithout a more sophisticated and expensive system, such as a LIMS.