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Pathways correlated with a type 2 diabetic phenotype. The table shows p-values for the three pathways most correlated with blood glucose concentration as measured two hours after an oral glucose tolerance test (OGTT). r is the Pearson correlation. Also shown are p-values, generally indicating low significance levels, for these pathways determined from t-statistic comparisons between DM2 (type 2 diabetic) and NGT (normal glucose tolerance). |
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| Comparison |
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| (genes in data set/total genes in pathway) Pathway |
glucose after OGTT |
DM2 vs. NGT |
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| (96/123) Oxidative phosphorylation |
0.031 (r = -0.517) |
0.565 (down in DM2) |
| (6/6) Activation of cAMP-dependent protein kinase |
0.062 (r = +0.474) |
0.395 (up in DM2) |
| (35/40) ATP synthesis |
0.166 (r = -0.432) |
0.855 (down in DM2) |
Tomfohr et al. BMC Bioinformatics 2005 6:225 doi:10.1186/1471-2105-6-225 |
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