Table 2

Disulfied intermediates experimentally observed in the oxidative folding of various proteins

Protein

Disulfide intermediates¹

Ref.

Bovine pancreatic trypsin inhibitor (BPTI)

3–5; 1–6; 3–5, 1–2;

3–5, 1–4; 3–5, 2–4;

1–6, 2–4; 3–5, 1–6;

1–6, 3–5, 2–4;

[26, 27]

Insulin-like growth factor (IGF)

2–6; 2–6, 3–5; 2–6, 1–4;

2–6, 4–5; 2–6, 1–3;

2–6, 1–3, 4–5; 1–4, 2–6, 3–5;

[28-30]

Epidermal growth factor (EGF)

2–3; 1–2; 4–6; 5–6;

3–4; 2–4, 5–6; 2–5, 3–4;

1–6, 2–5, 3–4; 1–2, 3–4, 5–6;

1–3, 2–4, 5–6;

[31]

¹The intermediates are described with the notation given in Figure 2. The native disulfide connectivity is in bold, the fully reduced species is not included.

Ágoston et al. BMC Bioinformatics 2005 6:19   doi:10.1186/1471-2105-6-19