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Open Access Software

FACT – a framework for the functional interpretation of high-throughput experiments

Felix Kokocinski12*, Nicolas Delhomme1, Gunnar Wrobel1, Lars Hummerich1, Grischa Toedt1 and Peter Lichter1

Author Affiliations

1 Molecular Genetics, Deutsches Krebsforschungszentrum, 69115 Heidelberg, Germany

2 Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1HH, UK

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BMC Bioinformatics 2005, 6:161  doi:10.1186/1471-2105-6-161

Published: 28 June 2005

Abstract

Background

Interpreting the results of high-throughput experiments, such as those obtained from DNA-microarrays, is an often time-consuming task due to the high number of data-points that need to be analyzed in parallel. It is usually a matter of extensive testing and unknown beforehand, which of the possible approaches for the functional analysis will be the most informative

Results

To address this problem, we have developed the Flexible Annotation and Correlation Tool (FACT). FACT allows for detection of important patterns in large data sets by simplifying the integration of heterogeneous data sources and the subsequent application of different algorithms for statistical evaluation or visualization of the annotated data. The system is constantly extended to include additional annotation data and comparison methods.

Conclusion

FACT serves as a highly flexible framework for the explorative analysis of large genomic and proteomic result sets. The program can be used online; open source code and supplementary information are available at http://www.factweb.de webcite.