Figure 1.

Multi domain proteins Sequences with different domain compositions belong to the same family of Adenylate cyclases but form different "true" clusters (Pfam domains: RA: Ras association (RalGDS/AF-6) domain; LRR: Leucine Rich Repeats; PP2C: Protein phosphatase 2C; guanylate_cyc: Adenylate and Guanylate cyclase catalytic domain)