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Open Access Methodology article

The effects of normalization on the correlation structure of microarray data

Xing Qiu1, Andrew I Brooks2, Lev Klebanov13 and Andrei Yakovlev1*

Author Affiliations

1 Department of Biostatistics and Computational Biology, University of Rochester, New York 14642, USA

2 Functional Genomics Center, University of Rochester, 601 Elmwood Avenue, Rochester, New York 14642, USA

3 Department of Probability and Statistics, Charles University, Sokolovska 83, Praha-8, CZ-18675, Czech Republic

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BMC Bioinformatics 2005, 6:120  doi:10.1186/1471-2105-6-120

Published: 16 May 2005

Additional files

Additional File 1:

The effect of normalization with non-overlapping pairs of genes;

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Additional File 2:

The effect of normalization procedures on the correlation structure of simulated data;

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Additional File 3:

The effect of the quantile normalization on the distribution of the t-statistics across genes.

Format: PDF Size: 59KB Download file

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Open Data