Figure 1.

Comparison of the distance matrices derived from intra-molecular crystal contacts and from the PAM250 evolutionary substitution rates. In (a) D(S) is plotted in the upper triangle and D(P) in the lower, larger distances correspond to lighter shades. We have scaled D to average unity i.e. <D> = 1. It is apparent that the two matrices have a similar pattern. The correlation is shown explicitly in (b). The extent of correlation varies with the contact cut-off distance and peaks at a cut-off of 4.5Å, see (c). When contacts are scored by residue centroid proximity then the correlation is less strong, see (c).