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Open Access Software

Caryoscope: An Open Source Java application for viewing microarray data in a genomic context

Ihab AB Awad1, Christian A Rees1, Tina Hernandez-Boussard2, Catherine A Ball2 and Gavin Sherlock1*

Author Affiliations

1 Dept. of Genetics, 300 Pasteur Drive, Stanford University Medical School, Stanford, CA 94305-5120, USA

2 Dept. of Biochemistry, Stanford University School of Medicine, Stanford, CA 94305-5307, USA

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BMC Bioinformatics 2004, 5:151  doi:10.1186/1471-2105-5-151

Published: 15 October 2004

Abstract

Background

Microarray-based comparative genome hybridization experiments generate data that can be mapped onto the genome. These data are interpreted more easily when represented graphically in a genomic context.

Results

We have developed Caryoscope, which is an open source Java application for visualizing microarray data from array comparative genome hybridization experiments in a genomic context. Caryoscope can read General Feature Format files (GFF files), as well as comma- and tab-delimited files, that define the genomic positions of the microarray reporters for which data are obtained. The microarray data can be browsed using an interactive, zoomable interface, which helps users identify regions of chromosomal deletion or amplification. The graphical representation of the data can be exported in a number of graphic formats, including publication-quality formats such as PostScript.

Conclusion

Caryoscope is a useful tool that can aid in the visualization, exploration and interpretation of microarray data in a genomic context.