|
Retrospective study of the predictive capability of the "hypothetical relationships" generated by Chilibot |
||||
| Term 1 |
Tertiary nodes |
Term 2 |
References Analyzed |
Relationship Documented |
|
|
||||
| LTP |
PI-3K PKA CAMKII ACTIN ERK TAU PKC AMPA |
KV4.2 |
1960~2000 |
2001~2004 |
| LTP |
PKA ACTIN SYNAPTOPHYSIN PKC NMDA TAU AMPA PLC |
ERK |
1960~1995 |
1996~2000 |
| LTP |
PKA ACTIN NMDA TAU AMPA PLC |
ARC |
1960~1995 |
1996~2000 |
| LTP |
PKA ACTIN CREB PKC PLC |
PI-3K |
1960~1995 |
1996~2000 |
| LTP |
PKA ACTIN SYNAPTOPHYSIN PKC TAU |
ACTININ |
1960~1995 |
1996~2000 |
| LTP |
PKA CAMKII CREB PKC TAU |
ATF |
1960~1995 |
1996~2000 |
| LTP |
ZIF268 PKC NMDA PLC |
TRKB |
1960~1995 |
1996~2000 |
| LTP |
PKA CAMKII CREB |
CAMKIV |
1960~1995 |
1996~2000 |
| LTP |
ZIF268 PLC |
TRKA |
1960~1995 |
1996~2000 |
| LTP |
NMDA TAU PLC ACTIN |
ARC |
1960~1990 |
1996~2000 |
| LTP |
PKC TAU CAMKII ACTIN |
SYNAPSIN I |
1960~1990 |
1991~1995 |
| LTP |
PKC NMDA TAU ACTIN |
PKA |
1960~1990 |
1991~1995 |
| LTP |
TAU ACTIN |
SYNAPTOPHYSIN |
1960~1990 |
1991~1995 |
| LTP |
TAU ACTIN |
ACTININ |
1960~1990 |
1996~2000 |
| LTP |
ACTIN |
ZIF268 |
1960~1990 |
1991~1995 |
|
A "hypothetical relationship" is defined when two terms have no documented relationship, but share connections to the same tertiary node(s). To test the value of these relationships in predicting the findings of future research, 22 terms (i.e., term 2; see methods) known to be involved in long-term potentiation (LTP) (i.e. term 1) were queried by Chilibot, limiting the latest references analyzed to the years 1990, 1995, 2000, and 2004. The "hypothetical relationships" (i.e. term 1 is related to term 2) and the time periods when these hypothetical relationships were suggested and documented are listed. The original results of these searches including links to the PubMed abstracts are available [see additional file 5]. | ||||
Chen and Sharp BMC Bioinformatics 2004 5:147 doi:10.1186/1471-2105-5-147 |
||||