Table 3

Retrospective study of the predictive capability of the "hypothetical relationships" generated by Chilibot

Term 1

Tertiary nodes

Term 2

References Analyzed

Relationship Documented


LTP

PI-3K PKA CAMKII ACTIN ERK TAU PKC AMPA

KV4.2

1960~2000

2001~2004

LTP

PKA ACTIN SYNAPTOPHYSIN PKC NMDA TAU AMPA PLC

ERK

1960~1995

1996~2000

LTP

PKA ACTIN NMDA TAU AMPA PLC

ARC

1960~1995

1996~2000

LTP

PKA ACTIN CREB PKC PLC

PI-3K

1960~1995

1996~2000

LTP

PKA ACTIN SYNAPTOPHYSIN PKC TAU

ACTININ

1960~1995

1996~2000

LTP

PKA CAMKII CREB PKC TAU

ATF

1960~1995

1996~2000

LTP

ZIF268 PKC NMDA PLC

TRKB

1960~1995

1996~2000

LTP

PKA CAMKII CREB

CAMKIV

1960~1995

1996~2000

LTP

ZIF268 PLC

TRKA

1960~1995

1996~2000

LTP

NMDA TAU PLC ACTIN

ARC

1960~1990

1996~2000

LTP

PKC TAU CAMKII ACTIN

SYNAPSIN I

1960~1990

1991~1995

LTP

PKC NMDA TAU ACTIN

PKA

1960~1990

1991~1995

LTP

TAU ACTIN

SYNAPTOPHYSIN

1960~1990

1991~1995

LTP

TAU ACTIN

ACTININ

1960~1990

1996~2000

LTP

ACTIN

ZIF268

1960~1990

1991~1995


A "hypothetical relationship" is defined when two terms have no documented relationship, but share connections to the same tertiary node(s). To test the value of these relationships in predicting the findings of future research, 22 terms (i.e., term 2; see methods) known to be involved in long-term potentiation (LTP) (i.e. term 1) were queried by Chilibot, limiting the latest references analyzed to the years 1990, 1995, 2000, and 2004. The "hypothetical relationships" (i.e. term 1 is related to term 2) and the time periods when these hypothetical relationships were suggested and documented are listed. The original results of these searches including links to the PubMed abstracts are available [see additional file 5].

Chen and Sharp BMC Bioinformatics 2004 5:147   doi:10.1186/1471-2105-5-147

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