Decision tree for mouse movement through phenotyping domains. The computational tools contained within MuTrack are designed to control the flow of mutagenized mice through the different testing domains. Once representatives from a particular pedigree have been screened by all domains, they will be categorized as normal, within the scope of observed behaviour or phenotype of control pedigree members, or phenodeviant. Representatives of the latter categories are classified as putative mutants, or "putants", and are retested. Pedigrees continuing to express phenotypic deviations are further classified as confirmed putative mutants, or "cutants", and are re-tasked by MuTrack for heritability testing. If the phenodeviation persists in subsequent generations, mice from the pedigree are confirmed as mutants and are made available for distribution.
Baker et al. BMC Bioinformatics 2004 5:11 doi:10.1186/1471-2105-5-11