Table 3

The 18 most highly diverse and hence oldest superfamilies. The species column indicates the number of species this superfamily occurs in, the superkingdom column indicates whether the superfamily occurs in eukaryota (E), archaea (A), bacteria (B), and viruses (V), connectivity refers to the number of interaction partners.

Species

Superkingdoms

Connectivity

SCOP ID

Superfamily

270

VEBA

46

c.37.1

P-loop containing nucleotide triphosphate hydrolases

193

EBA

9

c.2.1

NAD(P)-binding Rossmann-fold domains

154

EBA

8

c.55.1

Actin-like ATPase domain

143

VEBA

8

d.144.1

Protein kinase-like (PK-like)

135

EBA

18

c.3.1

FAD/NAD(P)-binding domain

128

EBA

38

b.1.1

Immunoglobulin

98

EB

9

a.39.1

EF-hand

90

VEBA

11

a.4.5

Winged helix DNA-binding domain

66

EBA

11

d.15.4

2Fe-2S ferredoxin-like

65

EB

8

d.15.1

Ubiquitin-like

63

EBA

12

d.58.1

4Fe-4S ferredoxins

62

EBA

10

d.142.1

Glutathione synthetase ATP-binding domain-like

59

EB

11

a.3.1

Cytochrome c

48

EB

6

a.118.1

ARM repeat

37

EBA

9

c.1.4

FMN-linked oxidoreductases

32

EBA

7

d.145.1

FAD-binding domain

93

EBA

14

c.1.8

(Trans)glycosidases

55

EBA

7

d.92.1

Metalloproteases (zincins) catalytic domain

Bolser et al. BMC Bioinformatics 2003 4:45   doi:10.1186/1471-2105-4-45