Table 2

Genes with average conservation ratios of zero

Gene

Disease Association

# Mutations

CLN3

Batten Disease

5

PAX8

Thyroid Hypoplasia

2

PROP1

Pituitary Hormone Deficiency

2

RAG1

Omenn Syndrome, Immunodeficiency

7

WISP3

Pseudorheumatoid Dysplasia

2

The mutations in these genes are perfectly conserved by our method. See text for details.

Mooney and Klein BMC Bioinformatics 2002 3:24   doi:10.1186/1471-2105-3-24