The active site of Phenylethanolamine N-methyltransferase. The stucture of a monomer of Phenylethanolamine N-methyltransferase is shown as a ribbon. Panel A: S-adenosyl-L-homocysteine is shown with red sticks in its pocket whose surface is in pale red. 1,2,3,4-tetrahydroisoquinoline-7-sulfonamide is shown in blue in its pocket whose surface is in pale blue. Panel B: The pocket for S-adenosyl-L-homocysteine with Y35, Y40, Y85, Y27 and D101 shown with sticks coloured by atom types. Panel C: The pocket for 1,2,3,4-tetrahydroisoquinoline-7-sulfonamide with F182 and Y222 shown with sticks coloured by atom types.
Cammisa et al. BMC Bioinformatics 2013 14(Suppl 7):S9 doi:10.1186/1471-2105-14-S7-S9