Table 4

Illustration of the key steps in the proposed method

Correct S-S topology: C134-176, C247-C266


Initial Connectivity {pairs(bond, belief)}

MS/MS

SVM

CSP

(134-176, 0.80)

(134-247, 0.96)

(134-176, 021)

(247-266, 0.81)

(247-266, 0.21)

Primitive hypothesis

{(134-176), (247-266), (134-247)}

Power Set

{(134-176), (247-266), (134-247), {(134-176),(247-266)}}

Power set scoring (per method)

MS/MS

SVM

CSP

(134-176, 0.34)

(134-176, 0.00)

(134-176, 0.20)

(247-266, 0.33)

(247-266, 0.00)

(247-266, 0.20)

(134-247, 0.00)

(134-247, 1.00)

(134-247, 0.00)

{(134-176,247-266), 0.33}

{(134-176,247-266), 0.00}

{(134-176,247-266), 0.20}

Global S-S connectivity (per combination rule)

Dempster rule

Campos rule

Shafer rule

(134-176, 0.47)

(134-176, 0.15)

(134-176, 0.35)

(247-266, 0.47)

(247-266, 0.15)

(247-266, 0.36)

*Yager rule: no S-S bonds were found (belief assignments were lower than 0.01)


Singh and Murad BMC Bioinformatics 2013 14(Suppl 2):S20   doi:10.1186/1471-2105-14-S2-S20

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