Table 2

Semantic similarity analysis of tested genes.

OMIM Disorder

Gene Symbol

Similarity score


Input Gene

Known Associated


B-Cell Cll/Lymphoma 2

BCL2

CDKN2A

0.389

MYC

0.305

TP53

0.434

BRCA1

0.382

BRCA2

0.329

CCND1

0.247

ATM

0.370


Bipolar disorder

KLF12

RORA

0.636

RORB

0.759

ARNTL

0.636

HTR2A

0.301


Given two scenarios of different disorders, the table shows the similarities, computed using the Wang metrics score, among genes that are known to be associated with the pathologies and the ontologically enriched output gene lists.

Merelli et al. BMC Bioinformatics 2013 14(Suppl 1):S9   doi:10.1186/1471-2105-14-S1-S9

Open Data