Table 8

NCI-curated pathway associations of group of genes contributing to NMF inflammatory component
Pathway name Genes P-value
IL23-mediated signaling events CCL2, CXCL1, CXCL9, IL1B, JAK2, STAT1, STAT5A 2.18e-07
IL12-mediated signaling events GADD45B, IL1B, JAK2, MAP2K6, SOCS1, STAT1, STAT5A, STAT6 1.10e-06
IFN-gamma pathway CASP1, IL1B, IRF9, JAK2, SOCS1, STAT1 1.07e-05
Signaling events mediated by TCPTP EIF2AK2, PIK3R2, STAT1, STAT5A, STAT5B, STAT6 1.07e-05
IL27-mediated signaling events IL1B, JAK2, STAT1, STAT2, STAT5A 1.22e-05
CXCR3-mediated signaling events CXCL10, CXCL11, CXCL13, CXCL9, MAP2K6, PIK3R2 1.23e-05
GMCSF-mediated signaling events CCL2, JAK2, STAT1, STAT5A, STAT5B 6.24e-05
PDGFR-beta signaling pathway EIF2AK2, JAK2, PIK3R2, ARAP1, DOCK4, STAT1, STAT5A, STAT5B 1.38e-04

NCI-curated pathway associations of group of genes contributing to NMF inflammatory component, whose factor scores are shown in Figure 4 (Source: NCI pathway interaction database http://pid.nci.nih.gov webcite). Genes in uBLU factor are significantly better represented in the NCI-curated pathways than the genes in NMF (compare p-values here to those in Table 6).

Bazot et al.

Bazot et al. BMC Bioinformatics 2013 14:99   doi:10.1186/1471-2105-14-99

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