|NCI-curated pathway associations of group of genes contributing to uBLU inflammatory component|
|IFN-gamma pathway||CASP1, CEBPB, IL1B, IRF1, IRF9, PRKCD, SOCS1, STAT1, STAT3||1.34e-09|
|PDGFR-beta signaling pathway||DOCK4, EIF2AK2, FYN, HCK, LYN, PRKCD, SLA, SRC, STAT1, STAT3, STAT5A, STAT5B||3.26e-08|
|IL23-mediated signaling events||CCL2, CXCL1, CXCL9, IL1B, STAT1, STAT3, STAT5A||2.18e-07|
|Signaling events mediated by TCPTP||EIF2AK2, SRC, STAT1, STAT3, STAT5A, STAT5B, STAT6||6.38e-07|
|Signaling events mediated by PTP1B||FYN, HCK, LYN, SRC, STAT3, STAT5A, STAT5B||2.40e-06|
|GMCSF-mediated signaling events||CCL2, LYN, STAT1, STAT3, STAT5A, STAT5B||3.70e-06|
|IL12-mediated signaling events||HLA-A, IL1B, SOCS1, STAT1, STAT3, STAT5A, STAT6||1.32e-05|
|IL6-mediated signaling events||CEBPB, HCK, IRF1, PRKCD, STAT1, STAT3||1.80e-05|
NCI-curated pathway associations of group of genes contributing to uBLU inflammatory component, whose factor scores are shown in Figure 1 (Source: NCI pathway interaction database http://pid.nci.nih.gov webcite). Genes in uBLU factor are significantly better represented in the NCI-curated pathways than the genes in NMF (compare p-values here to those in Table 8).
Bazot et al.
Bazot et al. BMC Bioinformatics 2013 14:99 doi:10.1186/1471-2105-14-99