Table 6

NCI-curated pathway associations of group of genes contributing to uBLU inflammatory component
Pathway name Genes P-value
IFN-gamma pathway CASP1, CEBPB, IL1B, IRF1, IRF9, PRKCD, SOCS1, STAT1, STAT3 1.34e-09
PDGFR-beta signaling pathway DOCK4, EIF2AK2, FYN, HCK, LYN, PRKCD, SLA, SRC, STAT1, STAT3, STAT5A, STAT5B 3.26e-08
IL23-mediated signaling events CCL2, CXCL1, CXCL9, IL1B, STAT1, STAT3, STAT5A 2.18e-07
Signaling events mediated by TCPTP EIF2AK2, SRC, STAT1, STAT3, STAT5A, STAT5B, STAT6 6.38e-07
Signaling events mediated by PTP1B FYN, HCK, LYN, SRC, STAT3, STAT5A, STAT5B 2.40e-06
GMCSF-mediated signaling events CCL2, LYN, STAT1, STAT3, STAT5A, STAT5B 3.70e-06
IL12-mediated signaling events HLA-A, IL1B, SOCS1, STAT1, STAT3, STAT5A, STAT6 1.32e-05
IL6-mediated signaling events CEBPB, HCK, IRF1, PRKCD, STAT1, STAT3 1.80e-05

NCI-curated pathway associations of group of genes contributing to uBLU inflammatory component, whose factor scores are shown in Figure 1 (Source: NCI pathway interaction database http://pid.nci.nih.gov webcite). Genes in uBLU factor are significantly better represented in the NCI-curated pathways than the genes in NMF (compare p-values here to those in Table 8).

Bazot et al.

Bazot et al. BMC Bioinformatics 2013 14:99   doi:10.1186/1471-2105-14-99

Open Data