Unbiased estimation of cell type specific profiles. (a) Cell type frequencies were estimated using markers for IM-9 cells (green), Raji cells (blue), Jurkat cells (red), and THP-1 cells (purple). (b) DSA estimation of the gene expression profiles of IM-9 cells compared against true expression profiles measured using pure cell samples. (c) ROC analysis on differential gene expression analysis of estimated IM-9 cells vs. Jurkat cells using DSA.
Zhong et al. BMC Bioinformatics 2013 14:89 doi:10.1186/1471-2105-14-89