Table 2

Algorithm performance in biological datasets
Dataset Interrogated mark # group 1 # group 2 BioTile TileMap CHARM
# DERs returned
1 H3K9me3 12 9 5,315 62 83
2 DNA methylation 6 9 5,767 27 105
3 DNA methylation 10 9 5,558 821 100
Proportion of validated DERs found
1 H3K9me3 12 9 100% 28% 0%
2 DNA methylation 6 9 100% 9% 0%
3 DNA methylation 10 9 100% 9% 0%
Proportion of validated DERs significant
1 H3K9me3 12 9 71% 28% 0%
2 DNA methylation 6 9 45% 9% 0%
3 DNA methylation 10 9 55% 9% 0%

A table depicting algorithm performance when applied to datasets derived from the McGowan et al., and Suderman et al., studies investigating the effects of early life environmental influence on epigenetic marks in the hippocampus.

Guintivano et al.

Guintivano et al. BMC Bioinformatics 2013 14:76   doi:10.1186/1471-2105-14-76

Open Data