Coverage standardization factors. The ○ represent the standardization factors calculated using the fragment size distribution obtained from the paired-end data. The ∆ represent coverage standardization factors that would be needed for the read count method and the + for the extended read count method, where in both cases we used the fragment size distribution obtained from the paired-end data for the calculations. The × sign represent estimates of the standardization factors for which we used the kernel smoother.
van den Oord et al. BMC Bioinformatics 2013 14:50 doi:10.1186/1471-2105-14-50