Table 7

In vivo probe inhibitors/inducers/substrates of selected transporters
Transporter Inhibitor Inducer Substrate
P-gp Amiodarone, azithromycin, captopril, carvedilol, clarithromycin, conivaptan, cyclosporine, diltiazem, dronedarone, erythromycin, felodipine, itraconazole, ketoconazole, lopinavir and ritonavir, quercetin, quinidine, ranolazine, ticagrelor, verapamil Avasimibe, carbamazepine, phenytoin, rifampin, St John’s wort, tipranavir/ritonavir Aliskiren, ambrisentan, colchicine, dabigatran etexilate, digoxin, everolimus, fexofenadine, imatinib, lapatinib, maraviroc, nilotinib, posaconazole, ranolazine, saxagliptin, sirolimus, sitagliptin, talinolol, tolvaptan, topotecan
BCRP Cyclosporine, elacridar (GF120918), eltrombopag, gefitinib NA Methotrexate, mitoxantrone, imatinib, irrinotecan, lapatinib, rosuvastatin, sulfasalazine, topotecan
OATP1B1 Atazanavir, cyclosporine, eltrombopag, gemfibrozil, lopinavir, rifampin, ritonavir, saquinavir, tipranavir NA Atrasentan, atorvastatin, bosentan, ezetimibe, fluvastatin, glyburide, SN-38 (active metabolite of irinotecan), rosuvastatin, simvastatin acid, pitavastatin, pravastatin, repaglinide, rifampin, valsartan, olmesartan
OATP1B3 Atazanavir, cyclosporine, lopinavir, rifampin, ritonavir, saquinavir NA Atorvastatin, rosuvastatin, pitavastatin, telmisartan, valsartan, olmesartan
OCT2 Cimetidine, quinidine NA Amantadine, amiloride, cimetidine, dopamine, famotidine, memantine, metformin, pindolol, procainamide, ranitidine, varenicline, oxaliplatin
OAT1 Probenecid NA Adefovir, captopril, furosemide, lamivudine, methotrexate, oseltamivir, tenofovir, zalcitabine, zidovudine
OAT3 Probenecid cimetidine, diclofenac NA Acyclovir, bumetanide, ciprofloxacin, famotidine, furosemide, methotrexate, zidovudine, oseltamivir acid, (the active metabolite of oseltamivir), penicillin G, pravastatin, rosuvastatin, sitagliptin

Wu et al.

Wu et al. BMC Bioinformatics 2013 14:35   doi:10.1186/1471-2105-14-35

Open Data