Table 13

DDI extraction error analysis from testing DDI sets
No. Error categories Error type Frequency examples
In vivo In vitro
1 There are multiple drugs in the sentence, and the sentence is long. FP 6 34 PMID: 12426514. In 3 subjects with measurable concentrations in the single-dose study, rifampin significantly decreased the mean maximum plasma concentration (C(max)) and area under the plasma concentration-time curve from 0 to 24 h [AUC(0–24)] of praziquantel by 81% (P <.05) and 85% (P <.01), respectively, whereas rifampin significantly decreased the mean C(max) and AUC(0–24) of praziquantel by 74% (P <.05) and 80% (P <.01), respectively, in 5 subjects with measurable concentrations in the multiple-dose study
FN 2 17 PMID: 10608481. Erythromycin and ketoconazole showed a clear inhibitory effect on the 3-hydroxylation of lidocaine at 5 microM of lidocaine (IC50 9.9 microM and 13.9 microM, respectively), but did not show a consistent effect at 800 microM of lidocaine (IC50 >250 microM and 75.0 microM, respectively).
2 There is no direct DDI relationship between two drugs, but the presence of some words, such as dose, increase, and etc. may lead to a false positive prediction FP 6 14 PMID: 17192504. A significant fraction of patients to be treated with HMR1766 is expected to be maintained on warfarin
3 DDI is presented in an indirect way. FN 2 19 PMID: 11994058. In CYP2D6 poor metabolizers, systemic exposure was greater after chlorpheniramine alone than in extensive metabolizers, and administration of quinidine resulted in a slight increase in CLoral.
4 Design issue. Some NDDI are inferred due to some adjectives (little, minor, negligible) FP 1 3 PMID: 10223772. In contrast,the effect of ranitidine or ebrotidine on CYP3A activity in vivo seems to have little clinical significance.
5 Unknown FP 5 44 PMID: 10383922. CYP1A2, CYP2A6, and CYP2E1 activities were not significantly inhibited by azelastine and the two metabolites.
FN 6 26 PMID: 10681383. However, the most unusual result was the interaction between testosterone and nifedipine.

Wu et al.

Wu et al. BMC Bioinformatics 2013 14:35   doi:10.1186/1471-2105-14-35

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