Runtime on the 1bm8 Rosetta decoy set. The size varies from 1,000 to 60,000 structures. Durandal runs out of memory when the size exceeds 40,000 proteins. Calibur-lite takes more than 2 hours to finish a run when the number of proteins was more than 45,000.
Zhou and Wishart BMC Bioinformatics 2013 14:11 doi:10.1186/1471-2105-14-11