The Overall Best entry. A topological network map of SNPs produced by Iris. Each node represents a cluster of SNPs and nodes are connected with an edge if they have any SNPs in common. The starburst shape indicates subgroups of SNPs with distinct linkage disequilibrium patterns in the data set. A) Each flare of the starburst contains SNPs from a single locus and is labeled accordingly, except for the "Mixed" flare. The nodes are colored by SNP mutual information with disease. Higher mutual information values are colored red and indicate a stronger relationship. B) The nodes are colored by SNP ANOVA F-statistic with expression of CDH19. Higher F-statistics are colored red and indicate a stronger relationship. The flare with the red tip contains SNPs from the CDH19 locus; see label in A. C) The nodes are colored by F -statistic to expression of PCDH17. D) The nodes are colored by F -statistic to PCDH10. E) The nodes are colored by F -statistic to CDH11.
Bartlett et al. BMC Bioinformatics 2012 13(Suppl 8):S8 doi:10.1186/1471-2105-13-S8-S8