Artifacts encountered when using hierarchical techniques. (a) A purkinje cell from the Virtual Neuromorphology Electronic Database is shown with two errors introduced: (1) a gap in a fiber and (2) a geometric distortion. The red region indicates the error evaluated using a hierarchical metric. (b) Our proposed method correctly identifies the gap as a small geometric error corresponding with a single missing connection. (c) Our method can also identify a geometric distortion, even though there is no resulting error in topology. (d) Despite this error, edge mapping is consistent across the test case and ground truth.
Mayerich et al. BMC Bioinformatics 2012 13(Suppl 8):S7 doi:10.1186/1471-2105-13-S8-S7