Differentiate relevant and irrelevant proteins by classification. (xi, xj) is assumed to be a relevant pair and (xi, xk) is assumed to be an irrelevant pair. The contextual dissimilarity vectors of both pairs are distinguished by a binary SVM model.
Wang et al. BMC Bioinformatics 2012 13(Suppl 7):S2 doi:10.1186/1471-2105-13-S7-S2