Graphical model showing multi-locus dependencies. Dynamic Bayesian network used by MULTIPOOL to capture the dependence between nearby loci in a pooled sequencing experiment. Allele frequencies in the pool influence the mix of observed sequencing reads at each locus. Here, the causal allele is x2 and its value is determined by sampling N individuals to create the pool from the population allele frequency p (where indicates association).
Edwards and Gifford BMC Bioinformatics 2012 13(Suppl 6):S8 doi:10.1186/1471-2105-13-S6-S8