Argot2 algorithm. i) Position of the retrieved nodes in the GO graph (black circles) with their weights (W). White circles connected by dashed lines are pruned GO terms that are not present in the final GO-slim. ii) Filtering steps based on Z-score and G-score (see the main text). The yellow big circles are the representatives of the corresponding groups having the highest Total Score (TS) and are used for the annotation. iii) The hexagons report the cumulative weights of the GO nodes i.e. W2 is obtained by the sum of its child nodes marked as black circles (WB and WC). Node 4 does not contribute to the cumulative score, as it is a reconstructed parent from node C. It inherits the weight of node C only (WC,4).
Falda et al. BMC Bioinformatics 2012 13(Suppl 4):S14 doi:10.1186/1471-2105-13-S4-S14