Table 5

Identification of Previously Undiscovered Components by IPAD

PathwayID

PathwayName

p-value

AE

RE

MJI

C

1430728

Metabolism

4.32E-35

525

2.19

0.34

93

556833

Metabolism of lipids and lipoproteins

1.00E-13

175

2.25

0.27

91

453279

Mitotic G1-G1/S phases

2.41E-42

47

27.44

0.33

87

200137

AP-1 transcription factor network

2.36E-06

44

2.97

0.32

87

453279

Mitotic G1-G1/S phases

2.77E-09

78

2.73

0.30

87

200120

Direct p53 effectors

6.09E-07

70

2.4

0.27

85

69278

Cell Cycle, Mitotic

1.81E-14

166

2.37

0.28

82

1640170

Cell Cycle

1.51E-12

183

2.11

0.26

80

535734

Fatty acid, triacylglycerol, and ketone body metabolism

1.38E-07

81

2.35

0.26

79

71291

Metabolism of amino acids and derivatives

7.54E-15

120

2.9

0.33

76

DiseaseID

DiseaseName

p-value

AE

RE

MJI

C

MESH:D015228

Hypertriglyceridemia

1.60E-192

4573

2.09

0.77

79

MESH:D009468

Neuromuscular Diseases

4.34E-07

117

2.04

0.41

74

MESH:D009468

Neuromuscular Diseases

2.16E-293

4573

2.52

0.82

74

MESH:D052016

Mucositis

4.99E-199

4572

2.11

0.77

72

MESH:D002543

Cerebral Hemorrhage

7.21E-128

4572

1.8

0.73

72

MESH:D006463

Hemolytic-Uremic Syndrome

3.65E-215

4570

2.18

0.78

72

MESH:D020246

Venous Thrombosis

6.59E-106

4573

1.71

0.72

70

MESH:D013923

Thromboembolism

1.78E-123

4573

1.79

0.73

70

DrugID

DrugName

p-value

AE

RE

MJI

C

PA449383

Docetaxel

3.08E-02

52

1.89

0.36

24

PA449780

Glutathione

1.74E-10

20

10.48

0.24

13

PA131301952

Gefitinib

8.52E-17

29.88

10.84

0.395

8

PA451283

Rosiglitazone

7.73E-22

41.4

10.58

0.386

5

PA448803

Carboplatin

2.57E-15

27

11.36

0.397

5

OrganID

OrganName

p-value

AE

RE

MJI

C

liver

Liver

1.82E-17

179

2.72

0.40

84

Zhang and Drabier BMC Bioinformatics 2012 13(Suppl 15):S7   doi:10.1186/1471-2105-13-S15-S7