Table 4

Enrichment Analysis of Brain-Specific Markers

Rank

PathwayID

PathwayName

N

Pvalue

AE

RE

MJI


1

112315

Transmission across Chemical Synapses

190

0

27

17.26

0.2117

2

112316

Neuronal System

283

0

32

13.74

0.2232

3

hsa04723

Retrograde endocannabinoid signaling

116

4.68E-14

18

18.85

0.1713

4

112314

Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell

136

4.48E-13

18

16.08

0.1599

5

hsa04727

GABAergic synapse

98

5.48E-13

16

19.84

0.165

6

hsa04080

Neuroactive ligand-receptor interaction

401

4.42E-12

26

7.88

0.1678

7

977441

GABA A receptor activation

12

7.38E-09

7

70.87

0.3281

8

975298

Ligand-gated ion channel transport

25

1.41E-08

8

38.88

0.2017

9

977443

GABA receptor activation

53

1.30E-07

9

20.63

0.1318

10

hsa04724

Glutamatergic synapse

134

2.62E-07

12

10.88

0.1073

11

983712

Ion channel transport

61

3.20E-07

9

17.92

0.1206

12

420499

Class C/3 (Metabotropic glutamate/pheromone receptors)

15

5.19E-07

6

48.6

0.2313

13

888590

GABA synthesis, release, reuptake and degradation

19

1.52E-06

6

38.37

0.1891

14

399719

Trafficking of AMPA receptors

30

1.33E-05

6

24.3

0.1313

15

399721

Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity

30

1.33E-05

6

24.3

0.1313

16

112310

Neurotransmitter Release Cycle

36

3.03E-05

6

20.25

0.1146


Rank

DiseaseID

DiseaseName

N

Pvalue

AE

RE

MJI


1

MESH:D001764

Blepharospasm

699

0

45

5.52

0.1398

2

MESH:D012563

Schizophrenia, Paranoid

649

3.18E-12

40

5.29

0.1265

3

MESH:D002385

Cataplexy

723

1.33E-11

41

4.86

0.1264

4

MESH:D020187

REM Sleep Behavior Disorder

506

1.44E-11

34

5.76

0.1149

5

MESH:D020821

Dystonic Disorders

837

4.52E-10

41

4.2

0.1226

6

MESH:D015877

Miosis

1000

1.94E-09

44

3.77

0.1273

7

MESH:D001925

Brain Damage, Chronic

1732

1.20E-08

59

2.92

0.1582

8

MESH:D000341

Affective Disorders, Psychotic

700

1.50E-08

34

4.17

0.1056

9

MESH:D007415

Intestinal Obstruction

1293

2.33E-08

48

3.18

0.1334

10

MESH:D011681

Pupil Disorders

1612

2.61E-08

55

2.93

0.1486


Rank

DrugID

DrugName

N

Pvalue

AE

RE

MJI


1

DB01595

Nitrazepam

20

2.92E-08

10

29.64

0.3294

2

DB00349

Clobazam

19

4.26E-08

9

28.08

0.3083

3

DB00475

Chlordiazepoxide

19

4.26E-08

9

28.08

0.3083

4

DB00683

Midazolam

19

4.26E-08

9

28.08

0.3083

5

DB00690

Flurazepam

19

4.26E-08

9

28.08

0.3083

6

DB00842

Oxazepam

19

4.26E-08

9

28.08

0.3083

7

DB01558

Bromazepam

19

4.26E-08

9

28.08

0.3083


Rank

OrganID

OrganName

N

Pvalue

AE

RE

MJI


1

brain

brain

363

0

260

15.42

0.8581


Zhang and Drabier BMC Bioinformatics 2012 13(Suppl 15):S7   doi:10.1186/1471-2105-13-S15-S7

Open Data