Table 2

Results from the analysis of simulated datasets

10 Folds CV

Independent Test



sim

GRR

LD thr.

Model

CA

AUC

CA

AUC


1

1.5/3.0

r2 ≥ 0.6.

HNB

0.85 [0.81-0.87]

0.92 [0.91-0.95]

0.64

0.66

NB

0.80 [0.78-0.82]

0.90 [0.89-0.90]

0.69

0.70


r2 ≥ 0.8.

HNB

0.85 [0.81-0.89]

0.93 [0.90-0.95]

0.63

0.68

NB

0.80 [0.78-0.82]

0.90 [0.89-0.90]

0.69

0.70


2

1.5/3.0

r2 ≥ 0.6.

HNB

0.87 [0.83-0.93]

0.94 [0.89-0.98]

0.63

0.68

NB

0.83 [0.80-0.83]

0.87 [0.84-0.90]

0.59

0.63


r2 ≥ 0.8.

HNB

0.85 [0.80-0.87]

0.92 [0.88-0.94]

0.65

0.70

NB

0.83 [0.80-0.83]

0.87 [0.84-0.90]

0.59

0.63


3

1.5/3.0

r2 ≥ 0.6

HNB

0.73 [0.70-0.77]

0.82 [0.76-0.85]

0.65

0.72

NB

0.78 [0.69-0.80]

0.86 [0.77-0.94]

0.68

0.75


r2 ≥ 0.8

HNB

0.77 [0.70-0.80]

0.85 [0.80-0.88]

0.71

0.75

NB

0.78 [0.69-0.80]

0.86 [0.77-0.94]

0.68

0.75


4

2.0/4.0

r2 ≥ 0.6

HNB

0.78 [0.72-0.84]

0.85 [0.80-0.89]

0.74

0.80

NB

0.72 [0.64-0.81]

0.76 [0.72-0.86]

0.71

0.75


r2 ≥ 0.8

HNB

0.72 [0.64-0.81]

0.77 [0.71-0.88]

0.70

0.76

NB

0.72 [0.64-0.81]

0.76 [0.72-0.86]

0.71

0.75


5

2.0/4.0

r2 ≥ 0.6

HNB

0.82 [0.77-0.83]

0.89 [0.83-0.92]

0.73

0.80

NB

0.78 [0.73-0.80]

0.84 [0.77-0.85]

0.76

0.83


r2 ≥ 0.8

HNB

0.82 [0.78-0.83]

0.88 [0.84-0.90]

0.76

0.86

NB

0.78 [0.73-0.80]

0.84 [0.77-0.85]

0.76

0.83


6

2.0/4.0

r2 ≥ 0.6

HNB

0.77 [0.73-0.80]

0.85 [0.83-0.87]

0.71

0.79

NB

0.75 [0.68-0.77]

0.80 [0.76-0.82]

0.66

0.71


r2 ≥ 0.8

HNB

0.73 [0.67-0.77]

0.80 [0.79-0.82]

0.65

0.72

NB

0.75 [0.68-0.77]

0.79 [0.76-0.82]

0.66

0.71


7

3.0/6.0

r2 ≥ 0.6

HNB

0.83 [0.81-0.83]

0.91 [0.87-0.93]

0.76

0.84

NB

0.80 [0.77-0.83]

0.85 [0.83-0.88]

0.81

0.87


r2 ≥ 0.8

HNB

0.83 [0.80-0.86]

0.94 [0.93-0.94]

0.82

0.91

NB

0.80 [0.77-0.83]

0.85 [0.83-0.88]

0.81

0.87


8

3.0/6.0

r2 ≥ 0.6

HNB

0.83 [0.78-0.87]

0.91 [0.89-0.94]

0.78

0.83

NB

0.82 [0.80-0.86]

0.87 [0.82-0.94]

0.81

0.85


r2 ≥ 0.8

HNB

0.82 [0.77-0.86]

0.90 [0.85-0.94]

0.78

0.86

NB

0.82 [0.78-0.86]

0.87 [0.82-0.94]

0.81

0.85


9

3.0/6.0

r2 ≥ 0.6

HNB

0.92 [0.87-0.93]

0.96 [0.94-0.98]

0.86

0.92

NB

0.83 [0.83-0.87]

0.92 [0.92-0.95]

0.84

0.86


r2 ≥ 0.8

HNB

0.87 [0.87-0.92]

0.96 [0.93-0.97]

0.89

0.92

NB

0.83 [0.83-0.87]

0.92 [0.92-0.95]

0.84

0.86


CA, Median Classification Accuracy and 25% - 75% of the distribution; AUC, Median Area Under the Curve and 25% - 75% of the distribution. The 25% - 75% of the distribution are reported for results deriving from 10 Folds CV.

Majority Classifier CA and AUC for 10 Folds CV and Independent test sets: 0.50

Malovini et al. BMC Bioinformatics 2012 13(Suppl 14):S6   doi:10.1186/1471-2105-13-S14-S6

Open Data