Simulation of Model 1. The time unit is the week. The time separating a screenshot from the previous one is 10 weeks. The parameters of the model are listed in Table 1. The longitudinal initial size of the tumor spheroid is 3 mm. Screenshot number "0" is the state of the tumor after 10 weeks of treatment. In the spatial domain of tumor lesion each mesh hosts only tumor cells2. Blue regions are those occupied by more that 2000 tumor cells, yellow regions corresponds to areas of tissue with a number of tumor cells between 100 and 2000, and orange regions are those occupied by less that 100 tumor cells. The extension of the tumor increases linearly in time.
Lecca and Morpurgo BMC Bioinformatics 2012 13(Suppl 14):S14 doi:10.1186/1471-2105-13-S14-S14