Table 2

Model parameters.

Parameter

Description

Value


1, α2)

Oc and Ob growth rates

(3, 4) day-1

1, β1)

Oc and Ob death rates

(0.2, 0.02) day-1

(g11, g12, g22, g21)

Effectiveness of autocrine/paracrine regulation

(1.1, 1, 0, -0.5)

(k1, k2)

Resorption and formation rates

(0.0748, 0.0006395) day-1

gageing

Ageing factor

2

gpor

RANKL factor

0.1

γB

S. aureus growth rate

0.005 day-1

s

S. aureus carrying capacity

100

V

Effectiveness of antibiotic treatment

(0.005, 0.007) day-1

ttreat

Dosage time

(200, 400, 600) days

(f11, f12, f22, f21)

Effect of infection on regulation factors

(0.005, 0, 0.2, 0.005) day-1

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Steady levels of Oc and Ob

Control: (1.16, 231.72)

Osteoporosis: (1.78, 177.91)

Osteomyelitis: (5, 316)

(Oc0, Ob0, B0)

Initial states

Control: (11.16, 231.72, 1)

Osteoporosis: (11.78, 177.91, 1)

Osteomyelitis: (15, 316, 1)


Values have been adapted from literature (mainly [10,16]). Some parameters are specific to a particular scenario: gageing and gpor are relative to the osteoporosis model, while parameters γB, s, V, ttreat and (f11, f12, f22, f21) are specific to the osteomyelitis model.

Liò et al. BMC Bioinformatics 2012 13(Suppl 14):S12   doi:10.1186/1471-2105-13-S14-S12

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