Simulation results of the ODE model. Bone density (first row), number of osteoblasts (second row), and number of osteoclasts (third row) compared between control and osteoporotic (first column); control and osteomyelitis (second column); osteoporotic and osteomyelitis (third column). Red lines mark the steady states for the variables considered. Results show a negative remodelling balance in the osteoporotic case and much more critical in the osteomyelitis case. While we observe a higher (but constant) remodelling rate in the osteoporotic configuration, in the osteomyelitis scenario the remodelling period is unstable and longer.
Liò et al. BMC Bioinformatics 2012 13(Suppl 14):S12 doi:10.1186/1471-2105-13-S14-S12