Previously, a quantitative trait loci (QTL) for hearing loss on chromosome 16 in a 118 TNE and CAST background has been identified. The overlap of two of interval specific congenic recombinant strains (ISCRS) strains reduced the QTL interval into a 5,378,407 bps genome region.
By examining the genomic information of the QTL on chromosome 16, between the two flanking markers, D16mit191 and D16mit86, we identified a total of 84 genetic elements in the 5,378,407 bps genome region. Among these genetic elements, we found seven with potential function in hearing loss preference (Table 1). We then examined the SNPs, insertions and deletions, and gene expression levels of those seven genes.
Table 1. Candidate genes for hearing loss on Chr 16
Our current data suggest that the Kcne1 and Sod1 genes are potentially the most hearing loss relevant genes. However, further experiments and examination are still needed to confirm their candidacy. Several other candidate genes are also in the process of being identified.
Support for this research is partially from the NIAAA (1R01 AA016342), NIH, the Veterans Administration Medical Center, and DNA Discovery Core, University of Tennessee, Memphis, Tennessee.