## Table 2 |
||||||

The number of probabilities to be estimated in an IMM |
||||||

Sequence type |
k = 0 |
k = 1 |
k = 2 |
k = 3 |
k = 4 |
k = 5 |

DNA | 12 | 60 | 252 | 1020 | 4092 | 16380 |

Protein | 20 | 420 | 8420 | 168420 | 3368420 | 67368420 |

Codon | 61 | 3782 | 230763 | 14076604 | 858672905 | 52379047266 |

The columns represent the number of transition probabilities to be estimated with
an Interpolated Markov model from *k = 0* to *k = 5*, while the rows designate the different sequence types (DNA, codon and protein).
The number of probabilities in a *k*^{th} order IMM corresponds to the number of regression coefficients for the *k* + 1 word frequencies in the CPPLS method.

Mehmood * et al.*

Mehmood * et al.* *BMC Bioinformatics* 2012 **13**:97 doi:10.1186/1471-2105-13-97