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Open Access Software

GeVaDSs – decision support system for novel Genetic Vaccine development process

Jacek Blazewicz12, Marcin Borowski1, Wahiba Chaara345, Pawel Kedziora1, David Klatzmann3456, Piotr Lukasiak12, Adrien Six34 and Pawel Wojciechowski1*

Author Affiliations

1 Institute of Computing Science, Poznań University of Technology, 60-965 Poznań, Poland

2 Institute of Bioorganic Chemistry, Polish Academy of Sciences, Poznań, 61-714, Poland

3 CNRS, UMR 7211, Immunology, Immunopathology, Immunotherapy, 75013 Paris, France

4 UPMC Univ Paris 06, UMR 7211, Integrative Immunology team, 75013 Paris, France

5 AP-HP, Pitié Salpêtrière Hospital, Department of Biotherapy, 75013 Paris, France

6 INSERM, U959, Immunology, Immunopathology, Immunotherapy, 75013 Paris, France

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BMC Bioinformatics 2012, 13:91  doi:10.1186/1471-2105-13-91

Published: 10 May 2012

Abstract

Background

The lack of a uniform way for qualitative and quantitative evaluation of vaccine candidates under development led us to set up a standardized scheme for vaccine efficacy and safety evaluation. We developed and implemented molecular and immunology methods, and designed support tools for immunization data storage and analyses. Such collection can create a unique opportunity for immunologists to analyse data delivered from their laboratories.

Results

We designed and implemented GeVaDSs (Genetic Vaccine Decision Support system) an interactive system for efficient storage, integration, retrieval and representation of data. Moreover, GeVaDSs allows for relevant association and interpretation of data, and thus for knowledge-based generation of testable hypotheses of vaccine responses.

Conclusions

GeVaDSs has been tested by several laboratories in Europe, and proved its usefulness in vaccine analysis. Case study of its application is presented in the additional files. The system is available at: http://gevads.cs.put.poznan.pl/preview/ webcite(login: viewer, password: password).