Core-surface score variation across UniProt history. The core-surface scores improve on average as more sequence data has become available. Plotted are core-surface scores of a) biological interfaces (from DCbio, Ponstingl Dimer and PLP datasets) and b) crystal interfaces (from DCxtal and Ponstingl Monomer datasets). The lower the score the stronger the indication of biological interface (our cut-off for classifying bio/crystal is set at −1). The median score for UniProt version 1.0 (2003) is denoted by a dashed line. The chosen versions are separated in time by approximately one year.
Duarte et al. BMC Bioinformatics 2012 13:334 doi:10.1186/1471-2105-13-334