Our prediction accuracies on biological interfaces versus identity cut-offs used for homolog selection. The prediction accuracies of our 2 evolutionary methods (core-rim entropy ratio with solid lines and core-surface entropy score with dashed lines) is plotted against different identity cut-offs for selection of homologs to be included in the alignments. For all datasets accuracies are lower when more distant homologs are used in the alignments.
Duarte et al. BMC Bioinformatics 2012 13:334 doi:10.1186/1471-2105-13-334