Gene expression of example probe pairs for which the correlation and mutual information based measures disagree. (A) Gene expression of probe pairs highlighted by blue circles in Figure 2. (B) Gene expression of probe pairs highlighted by red circles in Figure 2. The Pearson correlation, bicor, AMI,UniversalVersion2 values and z-scores of the latter two measures are shown at the top. Mutual information is susceptible to outliers, sometimes detects unusual patterns that are hard to explain, and often misses linear relations that are captured by bicor.
Song et al. BMC Bioinformatics 2012 13:328 doi:10.1186/1471-2105-13-328