Effect of cross-talk ratio on robustness ofE. coliensembles. The robustness (SRR) values of different networks are plotted against the Cross-talk ratio. All the plots are for an ensemble of networks with the same number of nodes, edges and transcription factors as the E. coli reference where the other topological properties are chosen in random. SRR values for one node knockout, α = 0.05 and β = 1% for knockout, parametric and initial condition perturbation have been shown. Cross-talk influences all three types of robustness. Increasing cross-talk between transcription factors decreases knockout and parametric robustness. For initial condition perturbations, cross-talk has a dual effect on robustness.
Zamal and Ruths BMC Bioinformatics 2012 13:318 doi:10.1186/1471-2105-13-318