Robustness of different ensembles. The Steady State Retention Ratio (SRR) and Oscillation Retention Ratio (ORR) robustness measures for various ensembles. Plots a-c represent random ensembles drawn from the yeast reference and d-f represent ensembles drawn from the E. Coli reference. Each bar represents one ensemble and the height of the bar and associated error bar represent the mean and standard deviation, respectively, of the observed SRR/ ORR (robustness) values for the ensemble. Despite numerical differences in the robustness values, both yeast and E.coli results consistently show that the transcription factor-target ratio (TTR) and the Cross-talk ratio (CTR) are the most important determinants of robustness, whereas the Scale-free exponential distribution (SFE) is a minor robustness inducer.
Zamal and Ruths BMC Bioinformatics 2012 13:318 doi:10.1186/1471-2105-13-318