Multiple sequence alignments of representative human-specific gains of ubiquitylation sites. Human-specific ubiquitylation sites, which are marked by plus signs (+), and the surrounding regions for ERCC2 (A) and NBR1 (B) proteins are shown. The gained lysine residues are highlighted on a black background. The residues that are the same as those in the human sequence are marked with dots (.). Dashes (−) and asterisks (*) denote alignment gaps and stop codons, respectively. Unknown amino acids are indicated by ‘X’. Some of the non-primate species were removed to save space (see Additional file 2 for complete data). The three-letter code preceding each species refers to the major mammalian clade to which that species belongs: pri, Primates; eua, Euarchontoglires; lau, Laurasiatheria; afr, Afrotheria; xen, Xenarthra; met, Metatheria; and pro, Prototheria.
Kim and Hahn BMC Bioinformatics 2012 13:306 doi:10.1186/1471-2105-13-306