Simulated Common CNVs. A. If a simple linear fit fails, the gene affinity is estimated for each gene as the slope of the least-square-error tri-linear fit between MRD and RD for that gene. B and Cr2 values of a simple linear fit (B) and a tri-linear fit (C) as a function of the deleted allele frequency.
Wu et al. BMC Bioinformatics 2012 13:305 doi:10.1186/1471-2105-13-305