Table 1

Comparison of iMS2Flux and other available MS correction tools
Tool MSCorr CORRECTOR iMS2Flux FiatFlux corrMatGen (OpenFLUX)
MS Data Extractiona - - - -
MS Data Quality Check - -
MS Data Correction Methods:
NA / NOI e
OBM - - -
Proton loss/gain - - √/√ - -
Output ready for use in Flux-Software:
13CFlux/ 13CFlux2 - - √/√ - -
OpenFlux - - -
FiatFlux - - - -
Model development & analysis - - -
Quantification of isotope enrichment - - -
High-throughput capabilityb - -
Multiple labeling substrate / isotopec √/- √/√ √/√ - √/√
Analytical platform GC GC/LC GC/LC GC GC/LC
additional software requiredd proprietary - free proprietary proprietary
Full source code available - -

a directly from chromatogram files like net-cdf files.

b multiple compounds in multiple chromatograms.

c the data processing is independent from the utilized labeling substrate (e.g. uniformly labeled or different positional labeling) and can be adapted to other elements then carbon (e.g. nitrogen, oxygen).

d requires additional software in order to be used like MATLAB or PERL.

e functional support is provided but not directly integrated.

Abbreviatons: NA - Natural Abundance; NOI - Naturally Occuring stable Isotopes; OBM - Original Biomass; GC - Gas Chromatography; LC - Liquid Chromatography.

Poskar et al.

Poskar et al. BMC Bioinformatics 2012 13:295   doi:10.1186/1471-2105-13-295

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