Figure 3.

Ad hoc Ω_a choices for the Divergent (a) and (d), Artificial (b) and (e), and Titanium (c) and (f) data sets. (a)-(c) are histograms of the Ω_athreshold at which each cluster derived from a run of DADA with Ω_a=Ω_r=10⁻³rejoins some other nearby cluster. Genuine genotype counts are shown in blue and false positive counts are shown in red. The first gaps in these histograms were used to pick Ω_athresholds for reclustering the data, and are indicated by vertical dashed lines. (d)-(f) show the Ω_adiscrimination lines for the largest cluster in each data set (with 2294, 5479, and 1095 reads) for Ω_a=10⁻³and the associated ad hoc Ω_avalues.