Correlation of CAPPIC interaction confidence with semantic similarity of Gene Ontology co-annotations. Interactions from every network are ranked by confidence and divided into five equal sized bins (X-axis); for each bin, the average semantic similarity of GO biological process (blue) and cellular component (green) annotations of interacting proteins is shown (Y-axis). Additionally, the pale continuous lines correspond to the mean GO semantic similarity over the complete network rather than the separate bins. The dashed lines reflect the average GO semantic similarity of random pairs of proteins from the network.
Kamburov et al. BMC Bioinformatics 2012 13:262 doi:10.1186/1471-2105-13-262