Design of artificial SV11 RNA. Dot plot of base pair Boltzmann probabilities for the designed sequence for the bistable SV11 target. Superimposed on the dot plot is a plot of base pairs in the two metastable SV11 structures, shown with open squares in different shades of grey. The secondary structures are also shown in the same shades of grey. Dots reflecting Boltzmann probabilities were rescaled by a factor of 0.75 to clearly separate them from any enclosing square representing a structure base pairs. The two conformations, that share no base pairs, are also show:, the native state (top) and meta-stable state (bottom).
Lyngsø et al. BMC Bioinformatics 2012 13:260 doi:10.1186/1471-2105-13-260